LONGEVICA

The Art of Living Longer…

Our Mission

Scientifically honest research and identification of the main mechanisms that could lead to human Life Extension, based on the knowledge gained from agnostic mice experiments

Our Vision

  1. To find dozens of compounds with substantial and statistically significant life extension effect on long-lived mice

    (disrupt “the world with just one rapamycin”!)

  2. To understand and identify precise Mechanisms of Life Extension

  3. Building upon discovered mechanisms, to develop one or two “life extending drugs” that will enhance human health, reduce age-related diseases, and consequently extend healthspan and lifespan.

  4. To bring a new paradigm of healthy longevity in the world

Longevica Mice Study-1 (Oct. 2009 - July 2013):

General Description:

  • The Jackson Laboratory (JAX), CA (NCI)

  • 20,000 long-lived female mice (B6C3F1/J strain)

  • 1,033 well-characterized pharmacological compounds were tested (62 pharmacological classes)

  • Intervention started in five-month-old mice

  • Alexander Chikunov invested $13M into the study

Main Results:

  • 60 individual compounds showed life extension of >10%

  • 5 out of 60 compounds showed a statistically significant life extension effect of 16-22%

  • Only 2 out of 62 pharmacological classes showed a statistically significant correlation with life extension

Longevica is a company that has embraced an agnostic approach to the quest for life extension. From 2009 to 2013, we conducted the largest study on mice, testing 1,033 pharmacological compounds. We received data about how each of the compounds affected lifespan: shortened, extended, or no effect. What makes our experiment truly unique is that we didn't just test individual compounds in isolation; all of our compounds belong to one of the 62 pharmacological classes with well-known pharmacological mechanisms. We discovered that among these classes, only 2 showed a statistically significant correlation with life extension. This insight became crucial in shaping our contemporary hypotheses regarding the 2 main mechanisms of life extension.

Next Steps

At this moment, Longevica is actively seeking funding for 3 purposes:

  1. Our team's work on deepper research and proof of concept for each of the 2 mechanisms.

  2. Conduct “Longevica mice study-2” to retest the most promising compounds from the first experiment.

  3. Expand upon the commercial applications of our knowledge.